New Criteria for Alzheimer Disease and Mild Cognitive Impairment
نویسندگان
چکیده
منابع مشابه
Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment.
OBJECTIVE To characterize the course of cognitive decline during the prodromal phase of Alzheimer disease. DESIGN Longitudinal cohort study with up to 16 years of observation. PARTICIPANTS Older persons from 2 studies underwent annual clinical evaluations that included cognitive function testing and clinical classification of mild cognitive impairment, dementia, and Alzheimer disease. At ba...
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Introduction: Mild Cognitive Impairment (MCI), a disorder of the elderly people, is difficult to diagnose and often progresses to Alzheimer Disease (AD). Temporal region is one of the initial areas, which gets impaired in the early stage of AD. Therefore, auditory cortical evoked potential could be a valuable neuromarker for detecting MCI and AD. Methods: In this study, the thresholds of...
متن کاملPlasma multianalyte profiling in mild cognitive impairment and Alzheimer disease.
OBJECTIVES While plasma biomarkers have been proposed to aid in the clinical diagnosis of Alzheimer disease (AD), few biomarkers have been validated in independent patient cohorts. Here we aim to determine plasma biomarkers associated with AD in 2 independent cohorts and validate the findings in the multicenter Alzheimer's Disease Neuroimaging Initiative (ADNI). METHODS Using a targeted prote...
متن کاملAlzheimer disease biomarkers and insights into mild cognitive impairment.
Persons with mild cognitive impairment (MCI) have overt changes in thinking and memory, but they are still largely independent in daily affairs. They have a far higher rate of developing dementia (progressing to a more debilitating state of cognitive impairment) than cognitively normal persons, but at the individual patient level, prognosis is variable. Sometimes persons with MCI do not worsen ...
متن کاملIntrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease.
BACKGROUND Immunoreactivity for several chemokines and for their related receptors has been demonstrated in resident cells of the central nervous system, and the up-regulation of some of them is associated with pathological changes found in Alzheimer disease (AD). OBJECTIVE To determine interferon-gamma-inducible protein 10 (IP-10), monocyte chemotactic protein 1 (MCP-1), and interleukin 8 (I...
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ژورنال
عنوان ژورنال: The Neurologist
سال: 2012
ISSN: 1074-7931
DOI: 10.1097/nrl.0b013e31826a998d